| dc.description.abstract | This study aims to evaluate the bioactive compounds, antioxidant, and antidiabetic properties of
methanol, dichloromethane, and ethyl acetate extracts of Rhizophora mucronata mangrove leaves.
The R. mucronata leaf samples (1 kg) were extracted with methanol, followed by liquid-liquid
partition extraction with dichloromethane, and finally ethyl acetate solvent. The extraction
procedure was repeated three times for one 24-hour period. The phytochemical content of the
three extracts was determined using the color test method, followed by an antioxidant activity test
using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, and an Oral Glucose Tolerance Test
(OGTT) to detect antidiabetic activity. The phytochemical contents of methanol,
dichloromethane, and ethyl acetate extracts of R. mucronata mangrove leaves are alkaloids,
flavonoids, phenolic compounds, triterpenoids, steroids, saponins, and tannins. The antioxidant
activity of the ethyl acetate extract is categorized as extremely strong, with an IC50 value of 34.64
ppm. In addition, the ethyl acetate extracts reduced blood glucose levels in mice by 57.64% after
24 hours. The mangrove plant R. mucronata from the Sambera beach, particularly the ethyl acetate
extract, has the potential to be developed as a natural antioxidant and alternative anti-diabetic
medicine. | en_US |
