An Evaluation of the Antidiabetic and Antimicrobial Activity of an Ethanolic Extract from Rhizophora mucronata Leaf2023
Date
2023-08-30Author
Usman, Usman
Pintaka, Kusumaningtyas
Sukemi, Basri
Erwin, Erwin
Metadata
Show full item recordAbstract
The aim of this research was to determine the antidiabetic and antimicrobial properties of ethanolic
extract of Rhizophora mucronata leaves, as well as the phytochemical elements contained in the leaf
extract. Extracts from R. mucronata leaf samples were obtained by maceration in ethanol-based
solvents. The ethanolic extract of R. mucronata leaves is known to have an antidiabetic effect on mice,
evidenced by its ability to reduce blood glucose levels. Giving ethanol extract at a dose of 600 mg/kg
BW gives the greatest antidiabetic effect. The antibacterial activity of the extract against the tested
bacteria and fungi was also limited due to the presence of contaminants in the ethanolic extract. The
analysis of secondary metabolites using LC-MS revealed that the ethanolic extract of R. mucronata
leaves contained 25 different secondary metabolite compounds. Furthermore research to purify and
identify the compounds in the ethanolic extract of R. mucronata is required to develop this resource
as an antimicrobial and antidiabetic drug based on natural materials.