Chemical Composition and Anticancer of Macaranga hosei Leaves

Please use this identifier to cite or link to this item: http://repository.unmul.ac.id/handle/123456789/478

Title:	Chemical Composition and Anticancer of Macaranga hosei Leaves
Authors:	Marliana, Eva Astuti, Winni Kosala, Khemasili Hairani, Rita Tjahjandarie, Tjitjik Srie Tanjung, Mulyadi
Issue Date:	2018
Publisher:	Asian Journal of Chemistry
Abstract:	The anticancer activity of methanolic ectract and ethyl acetate fraction of Macaranga hosei leaves against HeLa cell lines were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Both extracts displayed anticancer activity with IC50 value of 36.18 and 7.01 µM, respectively, which can be suggested that M. Hosei is a great potential source of anticancer agents. In addition, two isoprenylated flavanones, 4’-O-methyl-8-isoprenyl eriodictyol (1) and 6-isoprenyl eriodictyol (2) have been isolated from ethyl acetate fraction. The structures of both compounds have been elucidated based on their spectroscopic data, including 1D and 2D NMR spectra. Keywords: Macaranga hosei, Anticancer, MTT Assay, Flavanones, Isoprenylated
URI:	http://repository-ds.unmul.ac.id:8080/handle/123456789/478
ISSN:	0975-427X
Appears in Collections:	A - Mathematics and Natural Sciences

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