Synthesis and toxicity test of 2’-hydroxy-5’-chloro-3,4-dymethoxychalcone

Abstract

This study was aimed to synthesis the chalcone derivative and tested its toxicity. Synthesis of 2'-hydroxy-5'-chloro-3,4-dimethoxychalcone carried out through Claisen Schmidt condensation at room temperature. The toxicity test prepared by Bhrine Shrimp Lethality Test (BSLT) to Artemia salina L. Analysis retrosynthetic gives the 2-hydroxy-5-chloro acetophenone and 3,4-dimethoxy benzaldehyde as starting materials. The desire chalcone was confirmed by 1H-NMR and 13C-NMR, also mass spectroscopy. The chalcone obtained in 83,27% and exhibited LC50 value in 974,99 ug/mL.