Cytotoxic triterpenoids from Chisocheton pentandrus

dc.contributor.author	Supriatno, Salam
dc.date.accessioned	2023-02-01T11:07:45Z
dc.date.available	2023-02-01T11:07:45Z
dc.date.issued	2021-03-26
dc.identifier.uri	http://repository.unmul.ac.id/handle/123456789/47560
dc.description.abstract	Eleven undescribed triterpenoids (pentandrucines A to K) were isolated from the n-hexane extract of the stem bark of Chisocheton pentandrus (Blanco) Merr. These comprised ten undescribed dammarane-type triterpenoids and one undescribed apotirucallane-type triterpenoid. Additionally, two dammarane-type triterpenoids, four apotirucallane-type triterpenoids and two tirucallane-type triterpenoids were also isolated. The chemical structures of pentandrucine A-K, were fully elucidated using 1D and 2D-NMR, and high resolution MS. All of the compounds were evaluated for cytotoxic activity against MCF-7 breast cancer cells in vitro. Melianodiol proved to be the most active with an IC50 of 16.84 μM comparing favourably with Cisplatin (13.2 μM).	en_US
dc.subject	Chisocheton pentandrus Meliaceae Pentandrucine A-K Cytotoxic activity MCF-7 Triterpenoid	en_US
dc.title	Cytotoxic triterpenoids from Chisocheton pentandrus	en_US