Cytotoxic triterpenoids from Chisocheton pentandrus
Abstract
Eleven undescribed triterpenoids (pentandrucines A to K) were isolated from the n-hexane extract of the stem
bark of Chisocheton pentandrus (Blanco) Merr. These comprised ten undescribed dammarane-type triterpenoids
and one undescribed apotirucallane-type triterpenoid. Additionally, two dammarane-type triterpenoids, four
apotirucallane-type triterpenoids and two tirucallane-type triterpenoids were also isolated. The chemical
structures of pentandrucine A-K, were fully elucidated using 1D and 2D-NMR, and high resolution MS. All of the
compounds were evaluated for cytotoxic activity against MCF-7 breast cancer cells in vitro. Melianodiol proved to
be the most active with an IC50 of 16.84 μM comparing favourably with Cisplatin (13.2 μM).
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- J - Pharmacy [579]