| dc.description.abstract | Background : Tampoi ( Baccaurea macrocarpa) is a tropical rainforest
plant that produces edible fruit and is native to Southeast Asia, especially
East Kalimantan, Indonesia. Previous research showed that Tampoi
potentially can be developed as a drug. It was reported that the extract of
Tampoi fruit displayed antioxidant activity, which was correlated with its
phenolic and flavonoid substances. There is no information about the
antioxidant activity of other parts of this plant, such as the bark, which might
also have this kind of activity. Therefore, the aim of this study was to
evaluate the phytochemical using GC-MS analysis, toxicity againt Artemia
salina, and antioxidant activity with DPPH radical scavenging method of the
bark of Tampoi.
Methods : The bark of Tampoi was extracted with methanol and
concentrated using rotary evaporator to obtain the methanol extract of the
bark. Secondary metabolites of this extract was determined using
phytochemical analysis. Afterward, the methanol extract was tested for its
toxicity using brine shrimp lethality test and antioxidant activity using the
2,2-diphenyl-1-picrylhydrazyl method.
Results : Phytochemical evaluation results showed that the methanol
extract of bark of this plant contains several secondary metabolites
including alkaloids, flavonoids, phenolics, steroids, and triterpenoids. The
toxicity test displayed no toxic property due to a LC value above 1000
ppm. For antioxidant activity, the result exhibited that the methanol extract
of bark of this plant could be categorized as an active extract with IC
value of 11.15 ppm. Moreover, based on gas chromatography-mass
spectrometer analysis, there are 37 isolated compounds from the bark, one
of which is methylparaben, a phenolic predicted to act as an antioxidant.
Conclusion: The results obtained in this research demonstrated that the
bark of Tampoi (B. macrocarpa) has potential as an antioxidant. | en_US |
