Synthesis and toxicity test of 2’-hydroxy-5’-chloro-3,4-dymethoxychalcone
Date
2021-09-28Author
Mulyani, Melia
Farah, Harra Ismi
Rusli, Rolan
Rahmadani, Agung
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Show full item recordAbstract
This study was aimed to synthesis the chalcone derivative and tested its toxicity. Synthesis of 2'-hydroxy-5'-chloro-3,4-dimethoxychalcone carried out through Claisen Schmidt condensation at room temperature. The toxicity test prepared by Bhrine Shrimp Lethality Test (BSLT) to Artemia salina L. Analysis retrosynthetic gives the 2-hydroxy-5-chloro acetophenone and 3,4-dimethoxy benzaldehyde as starting materials. The desire chalcone was confirmed by 1H-NMR and 13C-NMR, also mass spectroscopy. The chalcone obtained in 83,27% and exhibited LC50 value in 974,99 ug/mL.
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- P - Pharmacy [171]