Wound healing potency of Terminalia catappa in mice (Mus musculus)

Abstract

Leaves of Terminalia catappa and its phytoconstituents are well known as a natural promising medicine especially for wound healing agents. The purpose of the current research was to evaluate the wound healing potency of ethanolic and water extract of T. catappa either green or brown leaves in mice (Mus musculus) model. A group of mice were used and randomly divided into control, vaseline, povide iodine groups and treatment groups consisting ethanolic extract either green (GLE) or brown leaves (BLE), and water extract green (GLW) and brown (BLW) leaves of T. catappa as ointment. All mice were prepared for excision and treated with simple ointment once a day until the wound was enclosure. The percentage of wound enclosure was recorded every three days, while total DNA and hydroxyproline content were determined at day 12. Qualitative phytochemical assay was performed to determine the phytoconstituent in the leaves extract. The results found that mice treated with GLE and GLW had better wound healing at the day12, confirming that the wound healing activity was found to be better than control and Povidone-iodine group. Furthermore, hydroxyproline content were also found to be higher in all treated groups than control group. Present finding suggested that T. catappa leaves extract which contains important phytochemicals shows a good wound healing activity and can be used as alternative medicine for wound healing.