An anthraquinone derivative from Coptospella tomentosa (Blume) root (Merung)

Abstract

Coptosapelta tomentosa (Blume) (Merung) is a type of tropical plants traditionally being used as amedicine by the Dayak tribes in Indonesia. This experiment aims to identify compound in the class of anthraquinone derivative from the ethyl acetate fraction of Coptosapelta tomentosa (Blume) root. In this study, an anthraquinone derivative was isolated from the ethyl acetate fraction of Coptosapelta tomentosa root using flash column chromatography. The compound was identified as 1-hydroxy-2- (hydroxymethyl) anthracene-9,10-dione (digiferruginol) (1). The structure of 1 was established based on Ultraviolet Visible, Fourier Transformed Infra-Red (FTIR), Nuclear Magnetic Resonance (NMR), and Quadrupole Time-of-Flight Mass Spectrometry (UPLC/QToF-MS) spectroscopic data. The antitumor and antioxidant activities of this compound were investigated by MTT assay against murine leukemia P-388 cells and DPPH free radical scavenging method, respectively. Antitumor and antioxidant activity test results show that compound 1 may have potent antitumor property but with moderate antioxidant activity