EFEKTIFITAS EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN

Abstract

Annona muricata Linn (Soursop leaves) contain flavonoid compounds. Flavonoid compounds act as diabetes drugs. This reseach aimed to determine the effect of soursop leaf ethanol extract on alloxan-induced hypoglycemia in white male rats. In this study, four treatment groups were used, namely. negative control (K) received no treatment, positive control (K+) received treatment with metformin 9 mg, the first treatment (P1) 7.2 mg (ethanol extract) and the second group (P2) was treated with 14.4 mg (ethanol extract). Rats were satisfied first before being treated, then measured blood sugar levels were. Rats were induced with alloxan intraperitoneally (IP), then observed the development of their blood sugar levels for three days, and their blood sugar levels were checked once a day. For seven days, then given ethanol extract of Soursop leaves daily for five days. The results showed that the ethanol extract of soursop leaves could reduce blood glucose in the P1 group by 6.67 mg/mL and in the P2 group by 5.66 mg/mL. The results of the Kruskal-Wallis test obtained a significant value of 0.317, which indicates that the value is greater than 0.05, which means that there is no significant difference between the administration of metformin and the ethanol extract of Annona muricata L in reducing blood glucose in Rattus norvegicus rats.