Isolation of angiotensin converting enzyme (ACE) inhibitory activity quercetin from Peperomia pellucida

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DC Field	Value	Language
dc.contributor.author	Kurniawan, Agus
dc.contributor.author	Saputri, Fadlina Chany
dc.contributor.author	Rissyelly, Rissyelly
dc.contributor.author	Ahmad, Islamudin
dc.contributor.author	Mun'im, Abdul
dc.date.accessioned	2019-10-18T15:14:26Z
dc.date.available	2019-10-18T15:14:26Z
dc.date.issued	2016
dc.identifier.issn	2455-9563
dc.identifier.uri	http://repository-ds.unmul.ac.id:8080/handle/123456789/426
dc.description.abstract	Peperomia pellucida (L.) Kunth. (Piperaceae) is empirically used in traditional medicine to control blood pressure. The objective of this study was to isolate ACE inhibitor from aerial part of the plant. Using chromatography technique was isolated flavonoid as ACE inhibitor. The chemical structure was determined as 3’,4’, Dihydroxy-3-5-dimethoxy flavone-7-O-?-rhamnose based on the spectral data (UV, IR, LC-MS, 1H-NMR, 13C-NMR, and 2DNMR) and compared with that reference. In vitro assay of ACE inhibitory activity that showed IC50 of the compound was 7.72 ?g/mL. The result of kinetic suggested that the compound inhibit the enzyme activity by competing with the substrate for the active site. The results supported the traditional use of the plant antihypertensive.
dc.publisher	International Journal of Pharmtech Research
dc.title	Isolation of angiotensin converting enzyme (ACE) inhibitory activity quercetin from Peperomia pellucida
Appears in Collections:	J - Pharmacy

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