Uji aktivitas trakeospasmolitik ekstrak etanol Centella asiatica (L.) Urb. Pada Organ Terpisah Trakea Marmut Untuk Melihat Efek Antiasma

Abstract

Asthma is a chronic inflammatory airway disease characterized by the occurrence of reversible hyperresponsive and constriction of the airways. Asthma is still a major health problem in the world. The provision of anti-asthma drugs is the treatment of the disease. However, there are problems of drug side effects and problems costs incurred to purchase the drug, especially asthma is a chronic disease that requires long- term treatment. Thus it is necessary for natural based antiasthma drug development with affordable cost and fewer side effects. This study was conducted to test the potential of the ethanol extract of Centella asiatica (L.) Urb. which is traditionally used by Dayak tribe as cough medicine. This study was conducted to look at the tracheospasmolytics activity of the ethanol extract of C. asiatica on the isolated organ of guinea pig trachea to see the effect of antiasthma. The results showed the extract of C. asiatica had significant tracheospasmolytics activity when compared to the negative control. Although the vE max value of C. asiatica lower than aminophylline, the EC50 value is not much different from the aminophylline as a positive control. It is concluded that the ethanol extract of C. asiatica had the tracheospasmolytics effect based activity for antiasthma. Keywords: Centella asiatica, spasmolytic, trachea isolated organ