dc.contributor.author | Tiwari, Sagar | |
dc.contributor.author | KC, Niranjan | |
dc.contributor.author | Thapa, Sajan | |
dc.contributor.author | Ghimire, Anuja | |
dc.contributor.author | Bijukchhe, Sanjeev | |
dc.contributor.author | Sah, Guru Sharan | |
dc.contributor.author | Isnuwardana, Ronny | |
dc.date.accessioned | 2022-01-14T05:57:59Z | |
dc.date.available | 2022-01-14T05:57:59Z | |
dc.date.issued | 2021-12-02 | |
dc.identifier.citation | Tiwari S, Kc N, Thapa S, et al. Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis. Middle East Fertil Soc J. 2021;26(1):44. doi:10.1186/s43043-021-00089-w | en_US |
dc.identifier.other | doi: 10.1186/s43043-021-00089-w | |
dc.identifier.uri | http://repository.unmul.ac.id/handle/123456789/9306 | |
dc.description.abstract | Background
The novel beta-coronavirus disease (COVID-19) has infected millions of people globally with high risk among males than females. However, the effect of COVID-19 andrology is still a subject of dispute. We planned to analyze the overall consequences of COVID-19 on semen parameters and male sex hormones.
Main text
Systematic search was performed on MEDLINE and Scopus database until 11 June 2021. We included observational studies, which reported mean ± standard deviation of the semen parameters and serum sex hormones of those reproductive-aged males recovered from COVID-19 and controls who did not suffered from COVID-19. We used Random-effect model to pool the studies, as heterogeneity was present. The Q test and I2 evaluated heterogeneity. All articles were assessed with their quality and publication bias.
We assessed 966 articles for eligibility and found seven eligible studies. These 7 studies included 934 participants with mean age 37.34 ± 10.5 years. Random-effect model meta-analysis showed that men who recovered from COVID-19 had semen parameters less than those who had not suffered from COVID-19. The overall mean difference (MD) [95% confidence interval (CI)] in semen volume, sperm concentration, sperm number, and progressive sperm motility was − 0.20 (− 0.45, 0.05) ml, − 16.59 (− 34.82, 1.65) millions/ml, − 45.44 (− 84.56, − 6.31) millions per ejaculate, − 1.73 (− 8.20, 4.75) percentage respectively. Considering sex hormones, luteinizing hormone and prolactin levels were higher among those recovered with a significant MD (95% CI) of 3.47 (1.59, 5.35)U l−1 and 3.21 (1.71, 4.72)ng ml−1 respectively.
Conclusion
We found that COVID-19 affects both semen parameters and sexual hormones. However, the mechanism for testicular involvement remains doubtful.
Trial registration
PROSPERO CRD42021259445 | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Middle East Fertility Society | en_US |
dc.subject | COVID-19, Infertility, Male, Meta-analysis, Semen, SARS-CoV-2 | en_US |
dc.title | Semen parameters in men recovered from COVID-19: a systematic review and metaanalysis | en_US |
dc.type | Article | en_US |