| dc.description.abstract | Cocor bebek Plants (Kalanchoe pinnata) has been observed to have a potent
immunosuppressant compounds in BALB/c mice with Delayed Type Hypersensitivity test
(DTH). Compounds are efficacious immunosuppression can be used for treatment of
autoimmune diseases such as lupus. The purpose of this study was knowing the class of
compounds in leaf extracts cocor bebek and test whether the extract can prevent the
occurrence of lupus in test animals. Methods: In this study the identification of classes of
compounds present in Cocor bebek leaf extracts and testing imunnosupression activities from
test animals BALB/c mice induced lupus using 2,6,10,14 tetramethylpentadecane (TMPD).
Parameters measured lupus glomerulonephritis which was known by the presence of
proteinuria using a test strip supported by data on changes in weight. Results: Extracts of
cocor bebek leaves positive contain tannins, flavonoids, saponins and steroid / triterpene.
Mice given the extract of Cocor bebek leaves every day until the 3rd month after not having
induced proteinuria, while untreated mice had proteinuria up to +2 (proteinuria levels> 30
mg / dL).
Key words : Cocor bebek, BALB/c mice, lupus, TMPD, glomerulonefritis | |
