| dc.description.abstract | The endophytic fungus, Clonostachys rosea B5-2 was isolated
from mangrove plants and subjected to the one strain many
compounds (OSMAC) methodology. By this approach, it was
found that modification of the culture media enhanced the
production of secondary metabolites by C. rosea B5-2. The apple
juice supplemented solid rice media led to significant changes in
the secondary metabolism of the fungus, C. rosea B5-2, and
induced the production of four new compounds, (-)-dihydrovertinolide (2), and clonostach acids A (3), B (4), and C (5) together
with the known compound, (-)-vertinolide (1). The new
compound (-)-dihydrovertinolide (2) exhibited phytotoxicity
against lettuce seedlings at a concentration of 50 mg/L
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