Cytotoxic triterpenoids from the bark of Chisocheton patens Blume (Meliaceae)

Abstract

Four new triterpenoids, namely, chisopaten A-D (1-4), were isolated from the n-hexane extract of the bark of Chisocheton patens Blume. The chemical structures of new compounds were elucidated on the basis of spectroscopic data interpretation. All isolated compounds were evaluated for their cytotoxic activity against MCF-7 breast cancer lines. Chisopaten A and C, showed strongest cytotoxicity activity with IC50 values of 4.01 ± 0.008 and 4.33 ± 0.009 μM, respectively.