A new limonoid from stem bark of Chisocheton pentandrus (Meliaceae)
Abstract
A new limonoid, pentandricine (1), along with three known
limonoids, ceramicine B (2), 6-de(acetyloxy)-23-oxochisocheton (3),
6-de(acetyloxy)-23-oxo-7-O-deacetylchisocheton (4), have been
isolated from the stembark of Chisocheton pentandrus. The chemical
structures of the new compound were elucidated on the basis of
spectroscopic evidence. All of the compounds were tested for their
cytotoxic effects against MCF-7 breast cancer cells. Compounds 1–4
showed weak and no cytotoxicity against MCF-7 breast cancer cells
with IC50 values of 369.84, 150.86, 208.93 and 120.09 μM, respectively.
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