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Turnitin Chemical Composition and Anticancer Activity of Macaranga hosei Leaves

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Turnitin Chemical Composition and Anticancer Activity of Macaranga hosei Leaves.pdf (2.060Mb)
Date
2018-02-28
Author
Kosala, Khemasili
Marliana, Eva
Astuti, Winni
Hairani, Rita
Tjahjandarie, Tjitjik Srie
Tanjung, Mulyadi
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Abstract
The anticancer activity of methanolic extract and ethyl acetate fraction of Macaranga hosei leaves against HeLa cell lines were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Both extracts displayed anticancer activity with IC50 values of 36.18 and 7.01 uM, respectively, which can be suggested that M.hosei is a great potential source of anticancer agents. In addition, two isoprenylated flavonones, 4'-O-methyl-8-isoprenyl eriodictyol (1) and 6-isoprenyl eriodictyol (2) have been isolated from ethyl acetate fraction. The structures of both compounds have been elucidated based on their spectroscopic data, including 1D and 2D NMR spectra.
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http://repository.unmul.ac.id/handle/123456789/3423
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Repository Universitas Mulawarman copyright ©   LP3M Universitas Mulawarman
Jalan Kuaro Kotak Pos 1068
Telp. (0541) 741118
Fax. (0541) 747479 - 732870
Samarinda 75119, Kalimantan Timur, Indonesia
Contact Us | Send Feedback