Show simple item record

dc.contributor.authorKosala, Khemasili
dc.contributor.authorWidodo, Moch Aris
dc.contributor.authorSantoso, Sanarto
dc.contributor.authorSoeharto, Setyawati
dc.date.accessioned2019-12-27T01:58:57Z
dc.date.available2019-12-27T01:58:57Z
dc.date.issued2019-04
dc.identifier.citationKosala K, Widodo MA, Santoso S, Soeharto S. In Vitro Study of The Bronchorelaxation Effect of Coptosapelta flavescens Korth Root's Extract and Fractions. 2019. Asian J Pharm Clin Res, 12(4) :94-97en_US
dc.identifier.issn2455-3891
dc.identifier.urihttp://repository.unmul.ac.id/handle/123456789/3422
dc.description.abstractObjective: This study aimed to compare the bronchorelaxation effect of the methanol extract, hexane fraction, ethyl acetate fraction, and methanol fraction of Coptosapelta flavescens Korth. roots (CFRs) on the isolated bronchial rings of guinea pig. Methods: Research design was experimental in which a 4-mm long bronchus of a male guinea pig was kept in an isolated organ bath containing Krebs-Henseleit solution at 37°C, pH 7.4, and flooded with carbogen gas. The bronchial ring was precontracted with methacholine and then given six doses of C. flavescens Korth. root’s methanol extract (MECFR) solution cumulatively. The extract’s solvent 10% dimethyl sulfoxide ethanol was used as negative control. This procedure was then repeated using CFRs hexane fraction (HFCFR) solution, CFRs ethyl acetate fraction (EAFCFR), and CFRs methanol fraction (MFCFR). Results: The bronchorelaxation effect of MECFR, MFCFR, EAFCFR, and HFCFR is shown by their dose-response curves (DRCs) which are significantly different compared with the extracts solvent’s DRC. The maximal efficacy (Emax) of MFCFR was the same (p>0.05) as the MECFRs Emax, but the EAFCFRs and HFCFRs Emax were smaller (p<0.05) than the MECFRs Emax. Conclusion: The bronchorelaxation effect of the MECFR on the guinea pig’s bronchial ring is similar to the CFRs methanol fraction, and is stronger than the CFRs ethyl acetate fraction and CFRs hexane fraction.en_US
dc.description.sponsorshipProvincial Government of East Kalimantanen_US
dc.language.isoenen_US
dc.publisherInnovare Academic Sciences Pvt Ltd. Asian J Pharm Clin Res, Vol 12, Issue 4, 2019, 94-97en_US
dc.subjectBronchorelaxation, Coptosapelta flavescens Korth. root, Extract, Fractionsen_US
dc.titleTurnitin In Vitro Study of The Bronchorelaxation Effect of Coptosapelta flavescens Korth Root's Extract and Fractionsen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record