| dc.description.abstract | The intensity and speed of antimalarial drugs resistance
highly depend on the consumption intensity of antimalarial
drugs. Higher intensity on consuming antimalarial drugs
accelerates the resistance to those drugs (Mustofa, 2009;
WHO, 2012). Limitations of antimalarial chemotherapy
indicate the importance on the discovery of new drugs which
ideally aimed at medicating new target. Some approaches
regarding with discoveries and development of antimalarial
drugs have been carried out including optimizing therapy
through existing drugs, developing the existing analogue
drugs, discovering new drugs from natural sources and
discovering active compound that works on new target. The
most innovative approach for chemotherapy is identification
on new target and identification on compound that works on
the target (Roshental, 2003; Herlina et al., 2007).
Indonesia has a high diversity of plants and some of those
have been proven to have activity as an antimalarial (Elfita et
al., 2011; Zein et al., 2013). Stem of Fibraurea tinctoria Lour
is widely available in East Kalimantan where the local people
call it as yellow root (Kulip, 1997; Ilona, 2003; Sangat et al.,
2003).
Plasmodium berghei is a unicellular protozoa that is a
parasite and one of the many species of malarial parasites that
infect mammals. Plasmodium berghei is an ideal model for
the study of malaria parasites compared to three species of
rodentia parasite in West Africa because it can be done on a
large scale, the data on gene structure mapping, methods for
genetically modifying parasites, and the presence of
distinctive clones and lines mutants that are genetically
modified (Muti'ah et al., 2010). This in vivo antimalarial
activity experiment used Plasmodium berghei ANKA.
Plasmodium berghei will be injected intraperitoneally into
mice (Mernvanga and Veronique, 2012). | en_US |
