PEMANFAATAN FRAKSI ETANOL DAUN JARUM TUJUH BILAH (Pereskia bleo (Kunth) D.C) SEBAGAI INHIBITOR XANTIN OKSIDASE DALAM PEMBENTUKAN ASAM URAT

Abstract

ABSTRACT : This research was conducted to determine the content of secondary metabolite contained in the extract and ethanol fraction of “Jarum tujuh bilah” leaves (Pereskia bleo(Kunth) DC)and and inhibition of xanthine oxidase activity obtained from the isolation of cow's milk. The xanthine oxidase activity is measured at a wavelength of 290 nm. The results of this research indicate that in the ethanol extract and fraction of“jarum tujuh bilah”leaveshave the secondary flavonoids, alkaloids and phenolic compounds. The highest inhibition of xanthine oxidase activity in the ethanol extract of “jarum tujuh bilah” leaves was 91.67%, while the inhibition of allopurinol was 50% and the ethanol fraction of “jarum tujuh bilah” leaves was seven blades by 90%.