| dc.description.abstract | A novel 2,3-epoxy naphthoquinol, named (6R,7R,8R)-theissenone
A (1), possessing an oxatricyclo[5.4.0.03,5]undeca-trien-2-one skeleton, together with two known compounds, (6S,7R,8R)-theissenone (2) and arthrinone (3), were produced by an endophytic
fungus, Arthrinium marii M-211, which was isolated from mangrove plants. The structure of 1, including the absolute stereochemistry, was elucidated by analysis of nuclear magnetic
resonance (NMR) and mass spectrometry (MS) data and timedependent density functional theory (TDDFT) calculations of electronic circular dichroism (ECD) spectra. Additionally, the absolute
structure of 2 was deduced as a diastereomer of 1 using ECD
spectral data analysis. Compounds 1, 2 and 3 exhibited cytotoxic
activity against the H4IIE rat hepatoma cells, with IC50 values of
67.5, 46.6 and 13.4 mM, respectively. | en_US |
