dc.contributor.author | Kosala, Khemasili | |
dc.contributor.author | Widodo, Moch Aris | |
dc.contributor.author | Santoso, Sanarto | |
dc.contributor.author | Karyono, Setyawati | |
dc.date.accessioned | 2019-12-27T01:30:09Z | |
dc.date.available | 2019-12-27T01:30:09Z | |
dc.date.issued | 2018-09 | |
dc.identifier.citation | Kosala K, Widodo MA, Santoso S, Karyono S. In vitro and In vivo Anti-inflammatory Activities of Coptosapelta flavescens Korth Root’s Methanol Extract. J App Pharm Sci, 2018; 8(09): 042-048. | en_US |
dc.identifier.issn | 2231-3354 | |
dc.identifier.uri | http://repository.unmul.ac.id/handle/123456789/3421 | |
dc.description.abstract | Coptosapelta flavescens Korth is a liana plant of the Rubiaceae family known in East Kalimantan as Akar Tambolekar
or Akar Merung. Its anti-inflammatory activity has not been scientifically proven in vitro or in vivo. The current
study aimed to prove the anti-inflammatory activity of C. flavescens root (CFR) methanol extract in vitro and in vivo.
The anti-inflammatory activity of CFR methanol extract was evaluated in vitro by examining its ability to stabilize
the membrane of hypotonicity-induced red blood cells (RBC), and in vivo study showed the effect on carrageenaninduced inflammation on the left leg of Wistar rats following its oral administration at 1 hour before, during, and
after carrageenan induction. Result of in vitro study revealed that the EC50 of CFR methanol extract was 1.905 ±
0.119 mg/ml, lower than that of indomethacin (10.288 ± 0.212 mg/ml). In vivo study showed that CFR methanol
extract at doses of 600 and 1200 mg/kg administered 1 hour before and during carrageenan induction exhibited antiinflammatory activity, but only the CFR methanol extract showed anti-inflammatory activity at a dose of 1200 mg/
kg when administered 1 hour after carrageenan induction. CFR methanol extract exhibited anti-inflammatory activity
both in vitro and in vivo. | en_US |
dc.description.sponsorship | Provincial Government of East Kalimantan | en_US |
dc.language.iso | en | en_US |
dc.publisher | MediPoeia, Journal of Applied Pharmaceutical Science 8 (09); 2018: 042-048 | en_US |
dc.subject | anti-inflammatory, carrageenan, Coptosapelta flavescens Korth, membrane stability. | en_US |
dc.title | Turnitin In vitro and In vivo Anti-inflammatory Activities of Coptosapelta flavescens Korth Root’s Methanol Extract | en_US |
dc.type | Article | en_US |